Synthesis of poly(O-phospho-L-serine) and its structure in aqueous solution

Authors
Ohkawa, K Saitoh, A Yamamoto, H
Citation
K. Ohkawa et al., Synthesis of poly(O-phospho-L-serine) and its structure in aqueous solution, MACRO RAPID, 20(12), 1999, pp. 619-621
Citations number
22
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
MACROMOLECULAR RAPID COMMUNICATIONS
ISSN journal
10221336 → ACNP
Volume
20
Issue
12
Year of publication
1999
Pages
619 - 621
Database
ISI
SICI code
1022-1336(199912)20:12<619:SOPAIS>2.0.ZU;2-L
Abstract
A novel polypeptide, poly(O-phospho-L-Ser), was synthesized through the fol lowing three steps: i) preparation of O-diphenylphospho-L-serine N-carboxya nhydride [Ser(PPh2) NCA]; ii) polymerization of Ser(PPh2) NCA; iii) removal of phenyl groups from poly[Ser(PPh2)]. The overall yield in the three-step synthesis was 71%, and the phospho-Ser content in poly(O-phospho-L-Ser) wa s 98 +/- 1%. Circular dichroism spectra suggest that the polypeptide has tw o different disordered structures in aqueous solution.