Preterm labor, cervical cerclage (especially when performed as an emer
gency procedure), and diabetes mellitus are all associated with an inc
reased risk of chorioamnionitis. It might be expected that the combina
tion of all 3 could lead to especially severe infection. We report suc
h a case. A woman with a history of two spontaneous midtrimester abort
ions had had cervical cerclage performed at 13 weeks. She was referred
at 24 weeks' gestation with preterm labor, and the cervix was found t
o be dilated. An emergency repeat cerclage was performed. The followin
g day, ultrasonography revealed the presence of intra-amniotic gas. in
fection was confirmed by the presence of a purulent cervical discharge
, a neutrophilia with a left shift, and an elevated C-reactive protein
level. The cervical stitch was removed and labor induced. The infant
was liveborn, but succumbed to the complications of prematurity and se
psis. E. coli was isolated. In her subsequent pregnancy, severe gestat
ional diabetes was diagnosed and following pregnancy, permanent diabet
es mellitus was confirmed. The combination of infection, diabetes, and
intact membranes may lead to a particularly severe form of chorioamni
onitis, with the production of gas within the amniotic cavity. infecti
on should be excluded before emergency cervical cerclage, especially i
n the woman with diabetes mellitus.