Ajw. Paige et al., A deletion on Chromosome 4 cosegregates with the whirler deafness mutation: exclusion of Orm1 as a candidate, MAMM GENOME, 11(1), 2000, pp. 51-57
Whirler (wi) mice display profound deafness and a head-tossing and circling
phenotype, showing an autosomal recessive mode of inheritance. The wi muta
tion has been shown to map close to the Orm gene cluster on mouse Chromosom
e (Chr) 4. We have, therefore, investigated the Orm loci as candidates for
the whirler gene. Detailed mapping and analysis of the Orm gene cluster in
both normal and whirler mice indicates the presence of a <48-kb deletion in
whirler mice that disrupts the Orm1 locus. The Orm1 locus is also deleted
in the CE/J mouse strain, and we discuss the candidature of Orm1 for the wh
irler gene.