Expression of metabotropic glutamate receptor subtype mRNA (mGluR1-8) in human cerebellum

THE expression of metabotropic glutamate receptor (mGluR) mRNAs in the huma n cerebellar neocortex was investigated using in situ hybridization. mGluR1 , 3 and 4 mRNAs were most abundant and widely distributed, whereas mGluR2, 5 and 7 mRNA expression was circumscript, mRNAs coding for mGluR1, 3, 4 and 7 were expressed in Purkinje cells. mGluR1 and 4 mRNAs detectable in granu le cells and mGluR1, 2, 3, 4 and 7 mRNAs in Golgi cells, mGluR5 mRNA was de tectable in putative Bergmann glia as well as mGluR3 mRNA, which was widely expressed in glial cells. mGluR8 mRNA expression was very low in a subset of stellate/basket cells of the molecular layer whereas mGluR6 mRNA was not detectable in the cerebellar cortex. (C) 1999 Lippincott Williams & Wilkin s.