Expression of 5-HT receptors and the 5-HT transporter in rat brain after electroconvulsive shock

Modulation of central 5-HT receptor sensitivity is implicated in the therap eutic response to electroconvulsive shock (ECS). Altered 5-HT receptor expr ession may play a role in this process. We have measured the mRNAs encoding 5-HT1A, 5-HT2A, 5-HT2C and 5-HT7 receptors, and the 5-HT transporter, in r at brain after single ECS, repeated ECS, and 3 weeks after repeated ECS. Hi ppocampal 5-HT1A receptor mRNA was decreased in CA4 and increased in dentat e gyrus by single or repeated ECS, with parallel alterations in [H-3]8-OH-D PAT binding site densities. Repeated ECS increased cortical [3H]ketanserin binding and 5-HT2A receptor mRNA. The other mRNAs were unchanged. The resul ts show that ECS has subtype specific, anatomically discrete, and temporall y selective effects on 5-HT receptor expression. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.