Structure and alternative splicing of the gene encoding the human beta(1) subunit of voltage dependent calcium channels

Authors
Hogan, K Gregg, RG Powers, PA
Citation
K. Hogan et al., Structure and alternative splicing of the gene encoding the human beta(1) subunit of voltage dependent calcium channels, NEUROSCI L, 277(2), 1999, pp. 111-114
Citations number
18
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
03043940 → ACNP
Volume
277
Issue
2
Year of publication
1999
Pages
111 - 114
Database
ISI
SICI code
0304-3940(199912)277:2<111:SAASOT>2.0.ZU;2-6
Abstract
The structure of the gene encoding the human brain beta(1) subunit of volta ge dependent calcium channels (CACNB1) was determined by comparison of its genomic sequence with beta(1) cDNA sequence. CACNB1 is distributed over 25 kb and contains 13 exons. Alternative splicing of CACNB1 RNA occurs within the central domain at exon 7, and the 3' domain at exon 13, producing the v ariably expressed beta(1a), beta(1b) and beta(1c) isoforms. Exon/intron bou ndaries and exon lengths are conserved for the nine exons shared by the bet a 1 and related brain beta 3 and beta(4) genes. (C) 1999 Elsevier Science I reland Ltd. All rights reserved.