CPP antagonizes hypoxia-induced changes in dopamine metabolism in the striatum of newborn rat

Treatment with 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), a potent and competitive N-methyl-D-aspartate antagonist, is able to reduce the hypoxia-induced increase in striatal dopamine level by 26% even after the hypoxic insult has occurred. The hypoxia-induced decrease of the striat al 3,4-dihydroxyphenylacetic acid level can also be reversed by CPP. This s tudy demonstrates that CPP can antagonize the hypoxia-induced changes in th e dopamine metabolism in the striatum of the newborn rat. (C) 1999 Publishe d by Elsevier Science Ireland Ltd. All rights reserved.