Adrenomedullin: Is there physiological relevance in the pathology and pharmacology?

The adrenomedullin gene encodes two potent hypotensive peptides, adrenomedu llin and proadrenomedullin NH2-terminal 20 peptide. As with other vasoactiv e peptides, the mast difficult challenge is to prove the physiological rele vance of their recognized pathological and pharmacological actions and to e stablish, against that physiological background their therapeutic potential .