Adenolymphoma (Warthin's tumor) with multiple sarcoid-like granulomas

Five cases of adenolymphoma (Warthin's tumor) (AL) with numerous sarcoid-li ke granulomas within the lymphoid stroma are described. All patients were m ales, aged from 44 to 71 years (mean 57.3 years); all tumors were localized in the parotid gland. Fine needle aspiration cytology was performed in two cases 7.5 and 2 weeks before operation, respectively. Microscopic examination demonstrated the typical structure of AL. In additi on, dispersed throughout the lymphoid stroma there were numerous granulomas formed by both epithelioid and multinucleated giant cells of Langhans type , strongly resembling sarcoidosis. The pathogenesis of the granulomatous change remains speculative. It could be caused by a toxic effect of the cysts' contents but probably not by its direct action; the spread of the fluid via sinuses into the lymphatic tissu e seems to be more probable. We presume that the previous FNA may have some triggering effect. Granulomatous transformation of the lymphoid stroma resembling sarcoidosis is rare, but should be included in the spectrum of secondary changes in AL. It is not limited to metaplastic AL; it can be seen in an otherwise typica l AL without any additional histologic changes Knowledge of a previous FNA and awareness of the possibility of this peculiar histologic change are nec essary to avoid incorrect diagnosis.