Cytotoxic activity of kaempferol glycosides against human leukaemic cell lines in vitro

Citation
K. Dimas et al., Cytotoxic activity of kaempferol glycosides against human leukaemic cell lines in vitro, PHARMAC RES, 41(1), 2000, pp. 85-88
Citations number
10
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMACOLOGICAL RESEARCH
ISSN journal
10436618 → ACNP
Volume
41
Issue
1
Year of publication
2000
Pages
85 - 88
Database
ISI
SICI code
1043-6618(200001)41:1<85:CAOKGA>2.0.ZU;2-0
Abstract
Two kaempferol coumaroyl glycosides (i.e. platanoside and tiliroside) isola ted from the methanolic extract of Platanus orientalis L. buds, were examin ed for their in vitro cytotoxic activity against a panel of human leukaemic cell lines. Platanoside (1) exhibited cytotoxic activity against most of t he cell lines tested, while tiliroside (2) was active against two of the ni ne tested cell lines. Compound 1, was examined for its effect on the uptake of [H-3]thymidine as a marker of DNA synthesis. Kaempferol was used as a c ontrol. (C) 2000 Academic Press.