The tithonus error in modern gerontology

Authors
Citation
Gc. Williams, The tithonus error in modern gerontology, Q REV BIOL, 74(4), 1999, pp. 405-415
Citations number
34
Categorie Soggetti
Biology
Journal title
QUARTERLY REVIEW OF BIOLOGY
ISSN journal
00335770 → ACNP
Volume
74
Issue
4
Year of publication
1999
Pages
405 - 415
Database
ISI
SICI code
0033-5770(199912)74:4<405:TTEIMG>2.0.ZU;2-H
Abstract
Tithonus asked Aurora for eternal life, when he meant eternal youth. Modern gerontological research makes the same mistake in its preoccupation with d eath, as if it were a programmed event in an organism's life history. Geron tology ought instead to investigate senescence, the decreasing effectivenes s of mechanisms by which adult organisms avoid death or loss of fitness. Su ch studies should measure rates of decline in a diversity of adaptations an d compare them within and between individuals and relate these rates and th eir correlations to genetic and environmental factors. The death of a studi ed organism must necessarily end its usefulness in providing valuable data. It is of little scientific significance.