K. Verhoeven et al., A GENE FOR AUTOSOMAL-DOMINANT NONSYNDROMIC HEARING-LOSS (DFNA12) MAPSTO CHROMOSOME 11Q22-24, American journal of human genetics, 60(5), 1997, pp. 1168-1173
We performed linkage analysis in a Belgian family with autosomal domin
ant midfrequency hearing loss, which has a prelingual onset and a nonp
rogressive course in most patients. We found LOD scores >6 with marker
s on chromosome 11q. Analysis of key recombinants maps this deafness g
ene (DFNA12) to a 36-cM interval on chromosome 11q22-24, between marke
rs D11S4120 and D11S912. The critical regions for the recessive deafne
ss locus DFNB2 and the dominant locus DFNA11, which were previously lo
calized to the long arm of chromosome 11, do not overlap with the cand
idate interval of DFNA12.