A GENE FOR AUTOSOMAL-DOMINANT NONSYNDROMIC HEARING-LOSS (DFNA12) MAPSTO CHROMOSOME 11Q22-24

Authors
VERHOEVEN K VANCAMP G GOVAERTS PJ BALEMANS W SCHATTEMAN I VERSTREKEN M VANLAER L SMITH RJH BROWN MR VANDEHEYNING PH SOMERS T OFFECIERS FE WILLEMS PJ
Citation
K. Verhoeven et al., A GENE FOR AUTOSOMAL-DOMINANT NONSYNDROMIC HEARING-LOSS (DFNA12) MAPSTO CHROMOSOME 11Q22-24, American journal of human genetics, 60(5), 1997, pp. 1168-1173
Citations number
25
Categorie Soggetti
Genetics & Heredity
Journal title
American journal of human genetics → ACNP
ISSN journal
00029297
Volume
60
Issue
5
Year of publication
1997
Pages
1168 - 1173
Database
ISI
SICI code
0002-9297(1997)60:5<1168:AGFANH>2.0.ZU;2-1
Abstract
We performed linkage analysis in a Belgian family with autosomal domin ant midfrequency hearing loss, which has a prelingual onset and a nonp rogressive course in most patients. We found LOD scores >6 with marker s on chromosome 11q. Analysis of key recombinants maps this deafness g ene (DFNA12) to a 36-cM interval on chromosome 11q22-24, between marke rs D11S4120 and D11S912. The critical regions for the recessive deafne ss locus DFNB2 and the dominant locus DFNA11, which were previously lo calized to the long arm of chromosome 11, do not overlap with the cand idate interval of DFNA12.