Effect of insulin therapy for diabetic cystopathy - Urodynamic and histological findings in a rabbit model

Objective: To investigate the efficacy of insulin therapy in preventing cys topathic changes in diabetes using a rabbit model. Materials and Methods: T wenty-four New Zealand white rabbits were studied in three groups: eight in group 1 as control, eight in group 2 with diabetes by administration intra venously alloxan hydrochloride and eight in group 3 administered insulin th erapy after induction of diabetes. Urodynamic investigations were carried o ut in three groups at the end of 8 weeks. Tissue sections prepared from all groups were studied histologically. Results: Bladder capacity and complian ce increased in diabetic non-treated group. There was no significant differ ence between the control group and the diabetic group treated with insulin. The neuropathic changes were observed in the diabetic group, whereas the f indings of the histological study were similar in the control and in the in sulin treatment group. Conclusions: This animal model indicates that insuli n therapy can prevent or delay urodynamic and histopathological changes in diabetes mellitus. These results must be supported by in vitro pharmacologi cal studies.