The aim of this paper is to carry out a detailed Bayesian population pharma
cokinetic analysis of a three-period cross-over study of the drug fluticaso
ne propionate carried out in 12 healthy male volunteers. The study was carr
ied out to characterize the pharmacokinetics of the drug, in particular to
investigate dose proportionality. We examine the appropriateness of modelli
ng assumptions via a variety of diagnostic techniques. We also examine the
effect of deleting time points at which the concentration was recorded as b
elow the limit of quantification, as opposed to including these points as c
ensored observations. We assess dose proportionality before carrying out a
final combined analysis of data from all three doses.