Protection of reproductive function in women with Hodgkin's disease in thecourse of polychemotherapy

Aim. To evaluate efficiency of estrogen-gestagen treatment for protection o f the ovaries during polychemotherapy. Materials and methods. Ultrasonography of the pelvic organs, radioimmunoass ay of LH, FSH, prolactin, E2, testosterone were performed in 95 women of ch ild-bearing age with different stages of Hodgkin's disease. Results. Cytostatic therapy of Hodgkin's disease had ovariotoxic effects an d led to amenorrhea in 83% of the examinees. Regular estrogen-gestagen trea tment protected ovaries in 86% of the patients. Conclusion. It is recommended for women to take estrogen-gestagen drugs to protect ovaries during polychemotherapy of Hodgkin's disease.