Reestablishment of plasma proteins after plasmapheresis in patients with paraproteinemic hemoblastosis

Aim. To study the effect of plasmapheresis (PA) on the changes in plasma to tal protein in the PA intervals in patients with paraproteinemia hemoblasto sis (PPH). Materials and methods. 26 PPH patients underwent 80 PA procedures to remove macromolecular pathological proteins and diminish blood viscosity. Before PA the patients were examined hematologically, biochemically. Total protein concentration in plasma was measured before and after PA, in the removed p lasma. Results. PA promoted total protein lowering in plasma to 65-85% of the base line irrespectively of PA technique. After PA the proteins gradually rose. Contents of circulation proteins were found unrelated to the number of PA p rocedures and averaged 70% of the PA-removed protein. Conclusion. The trends in recovery of plasma proteins after PA help to expl ain therapeutic effect in combination of PA with chemotherapy of paraprotei nemic hemoblastoses.