Synthesis of an elaborated heliquinomycin isocoumarin moiety

Authors
Thrash, TP Welton, TD Behar, V
Citation
Tp. Thrash et al., Synthesis of an elaborated heliquinomycin isocoumarin moiety, TETRAHEDR L, 41(1), 2000, pp. 29-31
Citations number
12
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
1
Year of publication
2000
Pages
29 - 31
Database
ISI
SICI code
0040-4039(20000101)41:1<29:SOAEHI>2.0.ZU;2-K
Abstract
Synthesis of a fully functionalized isocoumarin moiety 2 of DNA helicase in hibitor heliquinomycin (1) is reported. The key step is a modified condensa tion reaction of diethyl bromomalonate with readily accessible phthalaldehy dic acid derivative 3. Introduction of an allyl side chain is accomplished by Claisen rearrangement of allyl phenyl ether 8. (C) 1999 Elsevier Science Ltd. All rights reserved.