Chemoselective acylation of hydrazinopeptides: a novel and mild method forthe derivatization of peptides with sensitive fatty acids

Authors
Bonnet, D Rommens, C Gras-Masse, H Melnyk, O
Citation
D. Bonnet et al., Chemoselective acylation of hydrazinopeptides: a novel and mild method forthe derivatization of peptides with sensitive fatty acids, TETRAHEDR L, 41(1), 2000, pp. 45-48
Citations number
14
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
1
Year of publication
2000
Pages
45 - 48
Database
ISI
SICI code
0040-4039(20000101)41:1<45:CAOHAN>2.0.ZU;2-8
Abstract
N-terminal alpha-hydrazinoacetylpeptides were synthesized and chemoselectiv ely acylated on the hydrazine moiety with various fatty acid succinimidyl e sters or N-(cholesterylcarbonyloxy) succinimide. The acylation was performe d in water/2-methyl-propane-2-ol mixtures buffered at pH 5.1. The mild reac tion conditions allow the derivatization of peptides by sensitive fatty aci ds. (C) 1999 Elsevier Science Ltd. All rights reserved.