Asymmetric alkylation of aromatic aldehydes with diethylzinc catalyzed by a fluorous BINOL-Ti complex in an organic and fluorous biphase system

Authors
Nakamura, Y Takeuchi, S Ohgo, Y Curran, DP
Citation
Y. Nakamura et al., Asymmetric alkylation of aromatic aldehydes with diethylzinc catalyzed by a fluorous BINOL-Ti complex in an organic and fluorous biphase system, TETRAHEDR L, 41(1), 2000, pp. 57-60
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
1
Year of publication
2000
Pages
57 - 60
Database
ISI
SICI code
0040-4039(20000101)41:1<57:AAOAAW>2.0.ZU;2-#
Abstract
Fluorous chiral BINOL ((R)-FBINOL) was prepared by short reaction steps in good overall yield and was applied to the catalytic asymmetric alkylation i n a toluene and FC-72 biphase system. The (R)-FBINOL-Ti complex in the FC-7 2 phase was consecutively reused in the biphase system and the enantioselec tivity was still higher than 80% ee at the 5th reaction. (C) 1999 Elsevier Science Ltd. All rights reserved.