Y. Nakamura et al., Asymmetric alkylation of aromatic aldehydes with diethylzinc catalyzed by a fluorous BINOL-Ti complex in an organic and fluorous biphase system, TETRAHEDR L, 41(1), 2000, pp. 57-60
Fluorous chiral BINOL ((R)-FBINOL) was prepared by short reaction steps in
good overall yield and was applied to the catalytic asymmetric alkylation i
n a toluene and FC-72 biphase system. The (R)-FBINOL-Ti complex in the FC-7
2 phase was consecutively reused in the biphase system and the enantioselec
tivity was still higher than 80% ee at the 5th reaction. (C) 1999 Elsevier
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