VIEWS ON VAV

Vav is a 95 kDa protooncogene product whose expression is largely limi ted to cells of hematopoietic origin. Although reports on the role of Vav in Ras activation have generated conflicting results, it has becom e evident that Vav plays a crucial positive role in lymphocyte develop ment and stimulation. This article summarizes current knowledge on Vav and speculates on its role in hematopoietic cell signaling.