Utility and quality of autologous fresh frozen plasma and autologous fibrin glue for surgical patients

The quality of autologous fresh frozen plasma and autologous fibrin glue pr epared in our hospital was evaluated. The Auto-FFP was separated from whole blood or collected using a cell separator and the Auto-FG was then prepare d from the Auto-FFP. The Auto-FFP showed significantly higher levels of fib rinogen, Factor-V and Factor-VIII than commercially available FFP. The Auto -FG contained approximately 10 times the concentration of fibrinogen, Facto r-VIII, Factor-XIII, von Willbrand factor and fibronectin and 1.5 times tha t of alpha(2)-Plasminogen inhibitor compared to those of the Auto-FFP. When the Auto-FG was sprayed over diffusely bleeding sites from surgical wounds , hemostasis occurred within 5 s. These results suggest that Auto-FFP and A uto-FG may have sufficient utility and quality to reduce the use of allogen eic blood products. (C) 1999 Elsevier Science Ltd. All rights reserved.