Effects of levocabastine on lipid mediator release from guinea pig lung fragments

The effects of levocabastine, a novel histamine H-1-receptor antagonist, on lipid mediator release induced by antigen-antibody reaction from actively sensitized guinea pig lung fragments were studied. Levocabastine dose-depen dently inhibited the release of leukotriene C-4 from guinea pig lung fragme nts induced by antigen. A significant effect was observed with levocabastin e at a concentration of 10(-4) M. On the other hand, levocabastine produced no effect on the release of leukotriene E-4 or thromoboxane B-2. From thes e findings,it was concluded that levocabastine may be useful for relieving the nasal obstruction in allergic rhinitis caused by inhibition of leukotri ene C-4 release.