Early abortion by mifepristone (RU 486) followed by vaginal gel (meteneprost) versus oral (misoprostol) prostaglandin

Citation
D. Takkar et al., Early abortion by mifepristone (RU 486) followed by vaginal gel (meteneprost) versus oral (misoprostol) prostaglandin, ADV CONTRAC, 15(2), 1999, pp. 163-173
Citations number
18
Categorie Soggetti
Reproductive Medicine
Journal title
ADVANCES IN CONTRACEPTION
ISSN journal
02674874 → ACNP
Volume
15
Issue
2
Year of publication
1999
Pages
163 - 173
Database
ISI
SICI code
0267-4874(1999)15:2<163:EABM(4>2.0.ZU;2-I
Abstract
The present study was conducted to compare the therapeutic regimens of low- dose mifepristone (200 mg) plus vaginal meteneprost versus oral misoprostol in terms of efficacy and safety for medical termination of early pregnancy . A randomized clinical trial was conducted by the Department of Obstetrics and Gynecology at the All India Institute of Medical Sciences, New Delhi. A total of 101 subjects were enrolled within 56 days of amenorrhea. A singl e dose of 200 mg of mifepristone (RU 486) was given and, 48 hr later, prost aglandin was administered as either 5 mg of 9-methylene PGE(2) vaginal gel, meteneprost (classified as group I) or 600 mu g of oral PGE(1) derivative misoprostol (classified as group II). In group I, 50 subjects and in group II, 51 subjects were treated with the respective schedule. The success rate with mifepristone + misoprostol (group II) was 88.63% which was significan tly higher than that with mifepristone + meteneprost (group I) which was 82 % (p < 0.05). The average duration of bleeding in cases with complete abort ion was 8.95 +/- 5.67 and 9.77 +/- 6.51 in group I and II, respectively. Th ere were no serious side-effects. Only one subject in group I (2%) required blood transfusion for heavy bleeding. This study indicated that oral prost aglandin after a low dose of mifepristone (200 mg) could be developed into an effective method to terminate early pregnancy. Oral administration of bo th drugs would be a more convenient, feasible, private and acceptable regim en.