Late onset of metachronous bilateral testicular tumor and secondary non-germ-cell malignancy

In a large tumor registry study the 15-year cumulative risk of developing a second germ cell tumor for patients previously treated for testis cancer i s reported to be 3.9 % [29]. The relative risk is 36-times higher than in t he general population [27]. The incidence of a contralateral tumor is close ly related to the presence of testicular intraepithelial neoplasia (TIN). T estis cancer patients are also known to be at an increased risk of developi ng a second non-germ malignandy, especially in patients previously treated with radiotherapy. We report a 61 year old man with an asynchronous contralateral seminoma 29 years after orchiectomy for teratoblastoma and partial lung resection and r adiotherapy of lung metastasis, Two second non-germ cell intestinal carcino ma (sigma and rectum) were treated by sigma-rectum exstirpation one year be fore contralateral orchiectomy. The patient died two years later after intr aabdominal debulking surgery of metastatic disease of the colorectal carcin oma.