This paper outlines the structure of the National Institute on Aging (NIA),
the National Institutes of Health (NIH) agency that funds a majority of Al
zheimer disease (AD) research, and the process of submitting a federal gran
t application. The multiple steps of the grant application process, both fo
r the investigator preparing the application and the review process at NIH,
are described. The importance of speaking with a program officer from an i
nstitute and incorporating reviewers' comments into grant applications to s
trengthen the proposal is stressed.