Chondromyxoid fibroma of bone

Chondromyxoid fibroma is a benign, although potentially aggressive tumor, w ith a cartilage-like matrix, accounting for approximately 1% of all bone tu mors. It usually affects the metaphyseal region of long bones of patients i n their first or second decade of life. An additional peak of incidence has been observed between 50 and 70 years of age. Three cases are presented he re. 10-, 13-, and 52-year-old patients, with lesions in the proximal tibia, the proximal humerus, and the proximal femur, respectively. The literature is reviewed in terms of clinical behavior, diagnostic procedures, prognost ic factors. treatment, and outcome. Preferred treatment is complete local e xcision with turner-free margins. Intralesional curettage with or without l ocal adjuvants shows a local recurrence rate of approximately 25%. Radiatio n therapy may be useful in nonresectable cases but bears the well documente d risk of radiation-induced malignancies.