Synthesis and evaluation of anti-inflammatory activity of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones and their Michael addition products

Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones (4-10) were obtained in a one ste p synthesis by heating 3-aryl-5-mercapto-1,2,4-triazoles (3a-d) with chloro acetic acid and appropriate aromatic aldehyde ill acetic acid and acetic an hydride in the presence of anhydrous NaOAc. Michael type addition of cyclic secondary amines (N-methylpiperazine, piperidine) to 4-10 gave 2-phenyl-6- (alpha-aminoarylmethyl)thiazolo[3,2-b]-1,2,4-triazole-5-ols (4a-10b). The s tructures of the compounds were confirmed by spectral and elementary analys is. The compounds synthesized in previous and present studies were investig ated for their anti-inflammatory activities.