Platelet serotonin in juvenile mania

Serotonin is implicated in pathophysiology of affective disorders. Only a f ew and conflicting reports are available regarding the involvement of serot onin in juvenile depression. Juvenile mania has not been studied. Therefore , we investigated the role of central serotonin, using platelet serotonin u ptake and basal level as its peripheral model, in juvenile mania. Platelet serotonin uptake and basal level were compared in 15 manic and 10 normal ag e matched control juveniles. Both mean platelet serotonin uptake and mean p latelet serotonin basal level is significantly higher in manic state as com pared to normal controls (p<0.05). Increased central serotonergic function in juvenile mania is indicated by increased mean platelet serotonin uptake and basal level found in this study.