Effect of nifedipine on platelet serotonergic mechanisms in pregnancy induced hypertension

Nifedipine therapy 10 mg ED orally, carried out in 14 PIH pregnant subjects on comparison with 10 normal pregnant control clearly indicates as a valua ble therapeutic tool. Platelet serotonin uptake was markedly decreased with reduced serotonin content after 2 weeks, with increased platelet numbers. Clinically it controlled blood pressure, oedema and proteinuria. Calcium le vel was statistically decreased in post-therapy group along with potassium level with unaltered sodium level in blood. This study augmented the benefi cial effects of nifedipine on biochemical and clinical parameters in PIH su bjects.