Multinucleated giant cell formation by microglia: induction by interleukin(IL)-4 and IL-13

Authors
Suzumura, A Tamaru, T Yoshikawa, M Takayanagi, T
Citation
A. Suzumura et al., Multinucleated giant cell formation by microglia: induction by interleukin(IL)-4 and IL-13, BRAIN RES, 849(1-2), 1999, pp. 239-243
Citations number
21
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
849
Issue
1-2
Year of publication
1999
Pages
239 - 243
Database
ISI
SICI code
0006-8993(199912)849:1-2<239:MGCFBM>2.0.ZU;2-Z
Abstract
To investigate the cellular origin and the mechanisms of multinucleated gia nt cell (MGC) formation in the CNS, various cytokines were applied to isola ted murine microglia. All the single cytokines failed to induce MGC. Howeve r, interleukin (IL)-13 and IL-4 induced microglial MGC formation in the pre sence of colony stimulating factors, which was inhibited by either anti-IL- 13 or anti-fms antibody. T helper 2 (Th2)-derived cytokines can induce MGC formation even in the absence of infectious agents. (C) 1999 Published by E lsevier Science B.V. All rights reserved.