NG2 expression in MLL rearranged acute myeloid leukaemia is restricted to monoblastic cases

Expression of NG2 has been reported in the monoblastic cases. These data de monstrate that, if NG2 majority of paediatric acute leukaemia (AL) cases wi th MLL expression in AL is the (in)direct result of MLL rearrangement. We d emonstrated 7.1 positivity in 2/3 ment, such activation is restricted to a monoblastic paediatric and 4/11 adult MLL rearranged acute myeloid populati on in AML. They also have practical implications leukaemia (AML) but in 0/2 8 adult AML without MLL for NG2 diagnostic screening strategies. rearrangem ent, thus extending the 100% specificity to adult cases. Positivity correla ted with stage of maturation arrest since it was found in 0/6 immature AML but in 6/8 monoblastic cases. These data demonstrate that, if NG2 expressio n in AL is the (tin)direct result of MLL rearrangement, such activation is restricted to a monoblastic population in AML. They also have practical imp lications for NG2 diagnostic screening strategies.