Dermabrasion - a novel concept in the surgical management of sulphur mustard injuries

Since its first use on the battlefields of Northern France during the First World War (1914-1918), sulphur mustard has remained a significant chemical threat to military forces around the world. Progress towards an effective treatment for these injuries has been slow due to the lack of suitable anim al models upon which to study the toxicology and pathology. However, porcin e and human skin are similar in structure and exposures to sulphur mustard vapour have been performed on porcine models to define the development and subsequent resolution of mustard-induced skin injuries. Yucatan miniature ( n = 12) and large white (n = 6) pig models were used to assess the usefulne ss of mechanical dermabrasion in accelerating the naturally slow rate of he aling of sulphur mustard vapour-induced injuries to the skin. Burn injuries underwent debridement at 4 days postexposure and the resulting lesions wer e assessed at various time points up to 8 weeks post-abrasion. Rates of re-epithelialisation were accelerated in the dermabrasion (treated ) vs the control (untreated) group by up to a factor of three (ANOVA: p = 0 .0196, Yucatan; p = 0.165, large white pig). It was concluded that dermabra sion of sulphur mustard burns is a valuable procedure in the surgical manag ement of these injuries. (C) 2000 Elsevier Science Ltd and ISBI. All rights reserved.