Emerging translational therapies for mesothelioma

Malignant pleural mesothelioma remains a therapeutic. and diagnostic proble m. Translational mechanisms for treatment of the disease are emerging from newly learned characteristics of the tumor on a molecular, cellular, and ex tracellular basis. Although slow to reach the clinical arena, these potenti al strategies do show proof of principle in the in vitro and in vivo settin gs, and some, including adenoviral molecular chemotherapy, have completed p hase I testing. This review describes the rationale and status of these new er treatment ideas.