This paper addresses the two-machine flowshop problem to minimize mean flow
time where setup times are separated and sequence independent. Optimal solu
tions are obtained for two special cases. For the general case, two dominan
ce relations are established and their effectiveness in a branch-and-bound
algorithm is evaluated. It is shown that problems up to 35 jobs can be solv
ed optimally in a reasonable time. Moreover, for the general case, three he
uristic algorithms are proposed to find an approximate solution for larger
problems, and they are empirically evaluated to assess their effectiveness
in finding the optimal solution. Computational results show that one of the
heuristic algorithms has an overall average error of 0.7% from the optimal
value and that the error is independent of the number of jobs.