There are few randomized, prospective trials evaluating the optimal diagnos
tic and therapeutic strategies in the management of lower gastrointestinal
bleeding. However, recent data suggest that urgent colonoscopy represents a
safe and effective initial diagnostic approach. The role of tagged erythro
cyte scintigraphy is yet to be defined, but it may be of utility as a scree
ning test for visceral angiography. Colonoscopy and angiography both offer
substantial therapeutic options but remain of unproved benefit from a treat
ment standpoint; surgery continues to play an important role in the managem
ent of lower gastrointestinal bleeding. Obscure gastrointestinal bleeding,
which often presents as lower gastrointestinal bleeding, continues to be on
e of the most challenging diagnostic and therapeutic problems in gastroente
rology, Occult gastrointestinal bleeding, often arising from the lower gast
rointestinal tract, usually mandates gastrointestinal evaluation. (C) 2000
Lippincott Williams & Wilkins, Inc.