Association of hyperandrogenemia and hyperestrogenemia with type 2 diabetes in Hispanic postmenopausal women

OBJECTIVE- Accumulating evidence suggests that hyperandrogenemia may be a r isk factor for coronary heart disease (CHD) in women. The present study was carried out to test the hypothesis that hyperandrogenemia is associated wi th type 2 diabetes in women and thus may contribute to the increased risk o f CHD in women with type 2 diabetes. RESEARCH DESIGN AND METHODS- Sex hormones, sex hormone-binding globulin (SH BG), and risk factors for CHD were measured in 20 postmenopausal women with type 2 diabetes and in 29 control subjects. All of the diabetic and contro l subjects were Hispanic women aged >55 years who were not taking hormone r eplacement therapy, lipid-lowering drugs, or insulin and who were otherwise randomly chosen from a cohort of stroke-free subjects from the Northern Ma nhattan Stroke Study RESULTS- Mean age, BMI, total cholesterol, LDL cholesterol, LDL cholesterol , triglycerides, blood pressure, and smoking were not significantly differe nt between cases and control subjects, but waist-to-hip ratio (WHR) was sig nificantly higher in the diabetic subjects (P = 0.01). The mean levels of f ree testosterone (FT) (P = 0.01), dehydroepiandrosterone sulfate (P < 0.04) , and estradiol (P = 0.01) (controlled for WHR) were significantly higher i n the diabetic subjects; With the statistical outliers removed, the testost erone (P = 0.05) and androstenedione (P = 0.002) levels (controlled for WHR ) were also significantly higher in the diabetic subjects. The mean levels of estrone, cortisol, and SHBG were not significantly different. The result s were similar in the 10 diabetic subjects treated with diet only Significa nt positive correlations (controlled for age and BMI) were observed between FT or testosterone and cholesterol, LDL cholesterol, and blood pressure. CONCLUSIONS- Postmenopausal Hispanic women with type 2 diabetes had both hy perandrogenemia and hyperestrogenemia, and testosterone or FT correlated po sitively with risk factors for CHD. Hyperandrogenemia may be a link between diabetes and CHD in women.