N. Nohe et al., The low molecular weight heparin dalteparin for prophylaxis and therapy ofthrombosis in childhood: a report on 48 cases, EUR J PED, 158, 1999, pp. S134-S139
We investigated the efficacy, safety and relation of dose to plasma anti-Xa
activity of the low molecular weight heparin (LMWH) dalteparin in prophyla
xis and therapy of arterial and venous thrombosis in pediatric patients. A
total of 48 children were enrolled: 10 received dalteparin for prophylaxis
(group I), 8 for reocclusion prophylaxis following successful thrombolysis
(group II), 5 following failed thrombolysis (group III) and 23 for primary
antithrombotic therapy (group IV). Two children were treated with daltepari
n for pulmonary veno-occlusive disease (PVOD) and for primary pulmonary hyp
ertension (PPH), respectively. Outcome: In group I no thrombo-embolic event
occurred. In group II recanalization was maintained ro improved, in group
III vascular occlusion persisted under dalteparin. In group IV we saw compl
ete recanalization in 7/23 (30%), partial recanalization in 7/23 (30%) and
no recanalization in 9/23 (40%) cases. The child with PVOD had recanalizati
on proven by lung biopsy; the clinical condition of the child with PPH also
improved. Minor bleeding occurred in 2/48 (4%) children. For prophylaxis 9
5 +/- 52 (mean and SD) anti-Xa IU/kg BW, for therapy 129 +/- 43 (mean and S
D) anti-Xa IU/kg BW proved effective. For both prophylaxis and therapy the
required dose per kg BW was inversely related with age (r(2) = 0.64, P = 0.
017; r(2) = 0.13, P = 0.013).
Conclusion Dalteparin proved to be an effective and well tolerated drug for
prophylaxis and therapy of thrombosis in pediatric patients. Dose requirem
ent for effective treatment was higher in younger children and decreased wi
th age.