Synthesis and antinociceptive activity of (1-benzyl-2(3H)-benzimidazolon-3-yl) acetic acid derivatives

Authors
Nacak, S Dogruer, DS Sahin, MF
Citation
S. Nacak et al., Synthesis and antinociceptive activity of (1-benzyl-2(3H)-benzimidazolon-3-yl) acetic acid derivatives, FARMACO, 54(11-12), 1999, pp. 768-772
Citations number
18
Categorie Soggetti
Pharmacology & Toxicology
Journal title
FARMACO
ISSN journal
0014827X → ACNP
Volume
54
Issue
11-12
Year of publication
1999
Pages
768 - 772
Database
ISI
SICI code
0014-827X(199911/12)54:11-12<768:SAAAO(>2.0.ZU;2-#
Abstract
Eight (1-benzyl-2(3H)-benzimidazolon-3-yl)acetic acid derivatives have been synthesized and tested for antinociceptive activity in this study. All com pounds but one, at the oral dose of 100 mg/kg were comparable with aspirin. Ethyl (1-benzyl-2(3H)-benzimidazolon-3-yl)acetate (3), 4-[(1-benzyl-2(3H)- benzimidazolon-3-yl)acetyl]morpholine (6a) and 1-[(1-benzyl-2(3H)-benzimida zolon-3-yl)acetyl]pyrrolidine (6b) have shown more potent antinociceptive a ctivity than others. (C) 1999 Elsevier Science S.A. All rights reserved.