Synthesis and anticonvulsant activity of some (2/4-substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohydrazones

Authors
Cakir, B Yildirim, E Ercanli, T Erol, K Sahin, MF
Citation
B. Cakir et al., Synthesis and anticonvulsant activity of some (2/4-substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohydrazones, FARMACO, 54(11-12), 1999, pp. 842-845
Citations number
9
Categorie Soggetti
Pharmacology & Toxicology
Journal title
FARMACO
ISSN journal
0014827X → ACNP
Volume
54
Issue
11-12
Year of publication
1999
Pages
842 - 845
Database
ISI
SICI code
0014-827X(199911/12)54:11-12<842:SAAAOS>2.0.ZU;2-Y
Abstract
Fifteen new (2/4-substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohy drazones were synthesized and their structures were elucidated by NMR and e lemental analysis. Their anticonvulsant activity was tested by a pentylenet etrazole induced seizure test. Compounds 4e and 4h were found to be the mos t promising among the others. (C) 1999 Elsevier Science S.A. All rights res erved.