Synthesis and antinociceptive activity of some 3-substituted benzothiazolone derivatives

Authors
Cakir, B Ulucay, A Dogruer, DS Isimer, A Sahin, MF
Citation
B. Cakir et al., Synthesis and antinociceptive activity of some 3-substituted benzothiazolone derivatives, FARMACO, 54(11-12), 1999, pp. 846-851
Citations number
11
Categorie Soggetti
Pharmacology & Toxicology
Journal title
FARMACO
ISSN journal
0014827X → ACNP
Volume
54
Issue
11-12
Year of publication
1999
Pages
846 - 851
Database
ISI
SICI code
0014-827X(199911/12)54:11-12<846:SAAAOS>2.0.ZU;2-U
Abstract
Thirteen 3-substituted benzothiazolone derivatives have been synthesized. T heir chemical structures have been elucidated by IR and NMR spectral data a nd by elemental analyses. Among these compounds, 1-{3-[2(3H)-benzothiazolon -3-yl]propanoyl}morpholine (5b); 1-{3-[2(3H)-benzothiazolon-3-yl]propanoyl} -4-benzylpiperidine (5c); 1-{3-[2(3H)-benzothiazolon-3-yl]propanoyl}-4-phen ylpiperazine (5d); 3-[3-(4-benzylpiperidine-1-yl)propyl]-2(3H)-benzothiazol one (Sk); 3-[3-(4-benzylpiperazine-1-yl)propyl]-2(3H)-benzothiazolone (5I); 3-[3-(4-phenylpiperazine-1-yl)propyl]-2(3H)-benzothiazolone (5m) have been found to be significantly more active than the others. (C) 1999 Elsevier S cience S.A. All rights reserved.