Dysregulation of HMGIC in a uterine lipoleiomyoma with a complex rearrangement including chromosomes 7, 12, and 14

Uterine lipoleiomyomas are extremely rare tumors consisting of a mixture of mature adipocytes and smooth muscle cells. Using G-banding and FISH, we ch aracterized a complex rearrangement involving chromosomes 7, 8, 10, 11, 12, and 14 in one of these tumors. The region 14q23-24 was inserted into the l ong arm of the derivative chromosome 12, between the 3' end of HMGIC and 7q 21-22, another region often rearranged in uterine leiomyomas. Other portion s of chromosomes 12 and 14 were involved in derivative chromosomes 7, 11, 1 2, and 14. A chromosome 8 was involved in a three-way rearrangement includi ng the derivative 7, a ring chromosome 10, and a small derivative chromosom e 8 bearing segments of chromosomes 10 and 11. No abnormality of chromosome 5 was detected, in contrast to two previously reported cytogenetic analyse s of uterine lipoleiomyoma. The consistent finding of chromosomes 12 and 14 on different derivatives indicates that the t(12; 14) was a primary event. In addition, immunohistochemical studies showed that HMGI-C was aberrantly expressed in this tumor. These observations suggest that uterine lipoleiom yomas have a pathogenetic origin similar to that of typical leiomyomas. Gen es Chromosomes Cancer 27:209-215, 2000. (C) 2000 Wiley-Liss, Inc.