Cavernous sinus syndrome associated with nonsecretory myeloma

The case of a 53-year-old man who developed cavernous sinus syndrome (CSS) four years after being diagnosed as having nonsecretory myeloma is describe d, He was admitted with diplopia and dull pain over the right infraorbital and zygomatic region in June 1997, The cause of CSS was the intracranial in volvement of myeloma, which was diagnosed by fiberscopic biopsy. The result s of endocrinologic evaluation were almost normal. The response to radiothe rapy and chemotherapy was mild. CSS caused by nonsecretory myeloma is rare and its prognosis is poor. More aggressive chemotherapy with stem cell supp ort may be indicated.