Structure and sequence of the mouse V1a and V1b vasopressin receptor genes

The structural organization and 5'-flanking region of the mouse V1a and V1b vasopressin receptor genes were determined. The mouse Via receptor gene wa s located within an 8-kb XbaI fragment, and the mouse V1b receptor gene was located within a 14-kb EcoRV fragment. Both genes were comprised of two co ding exons that were separated by a 2.3-kb and a 8.0-kb intron, respectivel y, located before the respective seventh transmembrane domain of the recept or sequence. The availability of these genes would allow us to study the fu nctional role of V1a and V1b receptors by disrupting the gene in mice.