Production of a family of kinase-inhibiting lactones from fungal fermentations

Authors
Dombrowski, A Jenkins, R Raghoobar, S Bills, G Polishook, J Pelaez, F Burgess, B Zhao, A Huang, LY Zhang, Y Goetz, M
Citation
A. Dombrowski et al., Production of a family of kinase-inhibiting lactones from fungal fermentations, J ANTIBIOT, 52(12), 1999, pp. 1077-1085
Citations number
14
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
52
Issue
12
Year of publication
1999
Pages
1077 - 1085
Database
ISI
SICI code
0021-8820(199912)52:12<1077:POAFOK>2.0.ZU;2-S
Abstract
During the course of our screening for natural products from fungi, extract s of several cultures were found to make a family of related resorcylic aci d lactone compounds, which are potent inhibitors of MEK kinase. Comparative and empirical studies of fermentation conditions improved the titers of th e compounds of interest. Striking changes in the ratios and amounts of the major and minor compounds in some cases were achieved by manipulations of m edia composition.