Citation
J. Inokoshi et al., Funalenone, a novel collagenase inhibitor produced by Aspergillus niger, J ANTIBIOT, 52(12), 1999, pp. 1095-1100
Citations number
10
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820
→ ACNP
Volume
52
Issue
12
Year of publication
1999
Pages
1095 - 1100
Database
ISI
SICI code
0021-8820(199912)52:12<1095:FANCIP>2.0.ZU;2-Q
Abstract
Funalenone, a phenalene compound that inhibits type I collagenase (MMP-1),
was isolated from mycelium of Aspergillus niger FO-5904 by solvent extactio
n, ODS column chromatography, Sephadex LH-20 column chromatography and reve
rsed phase HPLC. Funalenone inhibited 50% of type I collagenase activity at
a concentration of 170 mu M, but inhibited 18.3% and 38.7% against 72 kDa
and 92 kDa type IV collagenase, respectively, at a concentration of 400 mu
m.