Eradication of Helicobacter pylori using 30 mg or 60 mg lansoprazole combined with amoxicillin and metronidazole: one and two weeks of a new triple therapy

A new triple therapy using a proton pump inhibitor and two antibiotics show s high efficiency against Helicobacter pylori infection. The aim of this st udy was to determine the optimal dose and duration of lansoprazole (LA) adm inistration in combination with amoxicillin (AMPC) and metronidazole (MNZ), A total of 91 patients were enrolled in this study. They were divided into four groups: group A, 2 weeks of 30mg LA once daily, 500mg AMPC tid, and 2 50mg MNZ tid; group B, 2 weeks of 30mg LA bid, 500mg AMPC lid, and 250mg MN Z lid; group C, 1 week of 30mg LA once daily, 500mg AMPC tid, and 250mg MNZ tid; group D, 1 week of 30mg LA bid, 500mg AMPC tid, and 250mg MNZ tid. H. pylori status was determined by the rapid urease test, culture, histology, and C-13-urea breath test before and at least 4 weeks after the end of the rapy. The cure rates in a per-protocol analysis and the incidence of advers e events in the evaluated patients were, respectively, 89.5% and 21.1% in g roup A, 100% and 20.0% in group B, 96.8% and 12.9% in group C, and 92.3% an d 26.9% in group D. Most of the adverse events were tolerated. All four reg imens in this study showed the same cure rates, and they were effective and well tolerated. One week of triple therapy using once-daily administration of 30mg LA is a good alternative.