Endoscopic and histological reversibility of gastric adenoma after eradication of Helicobacter pylori

Although epidemiological studies strongly suggest an association between He licobacter pylori infection and gastric carcinogenesis via a multistage pro cess, a causal link between them has not been demonstrated. We evaluated th e endoscopic and histological changes of gastric adenoma, which is consider ed a premalignant condition, after eradication of EI. pylori. Thirty-five I i. pylori-infected patients with gastric adenoma were treated with triple t herapy (lansoprazole 30mg/day, clarithromycin 400mg/day, and amoxicillin 15 00mg/day) for 1 week. Of these 35 patients, 30 (86%) exhibited no it pylori by culture or histology after the therapy. Of the 30 gastric adenomas, 7 d ecreased in size endoscopically; three gastric adenomas especially showed a pparent remission, although histological cure in these three patients was n ot apparent. Our results suggest that removal of It pylori infection may on ly mask a gastric adenoma endoscopically owing to the change around the gas tric mucosa.