DETERMINATION OF ACYCLOVIR IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

Authors
BOULIEU R GALLANT C SILBERSTEIN N
Citation
R. Boulieu et al., DETERMINATION OF ACYCLOVIR IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY, Journal of chromatography B. Biomedical sciences and applications, 693(1), 1997, pp. 233-236
Citations number
14
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Journal of chromatography B. Biomedical sciences and applications → ACNP
ISSN journal
13872273
Volume
693
Issue
1
Year of publication
1997
Pages
233 - 236
Database
ISI
SICI code
0378-4347(1997)693:1<233:DOAIHP>2.0.ZU;2-T
Abstract
A selective and sensitive isocratic high-performance liquid chromatogr aphic method for the analysis of acyclovir in human plasma was describ ed. Acid deproteinisation was used as sample treatment. Mean analytica l recoveries were higher than 94% at low and high concentrations, The quantification limit was 0.1 mg/l for a plasma volume of 500 mu l and precision study exhibits coefficients of variation lower than 5%. The method is suitable for therapeutic monitoring of acyclovir concentrati ons in organ-transplant recipients.