99mTc-MIBI scan in mammary Pagets disease: A case report

Technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) uptake is known to be increased in breast cancer because of increased brood flow from angiogenes is and heightened metabolism. We performed a 99mTc-MIBI scan in a patient w ith mammary Paget's disease. The patient had underlying invasive cancer in the same side of the breast. 99mTc-MIBI scan exhibited a scintigraphic imag e of the uptake from the invasive cancer lesion located deeply in the breas t toward the epidermis. 99mTc-MIBI showed an uptake in the deeply located i nvasive cancer lesion as well as nipple lesion. Especially, the delayed pha se of Tc-MIBI scan demonstrated the tumor site more accurately. In conclusi on, 99mTc-MIBI scan could be a useful adjunct to clinical decision making i n the management of Paget's disease of the breast.