We examine two-spin (2S) and cyclic four-spin (4S) magnetic interactions in
insulating ladder and two-dimensional (2D) cuprates. By a comparison of ei
genstates between d-p and Heisenberg models, we evaluate magnitudes of thes
e interactions. We find that the 4S interaction is similar to 10 % of neare
st neighboring 2S interaction, and a diagonal 2S interaction is considerabl
y small. The 4S interaction for a ladder cuprate is larger than that for 2D
one, and plays an important role in the low-energy excitation. The Heisenb
erg ladder with the obtained 2S and 4S interactions reproduces very well th
e experimental result of the temperature dependence of the magnetic suscept
ibility.